.disable
{
    border-style:none;
    border-width: thin;
    background-color:Transparent;
    color: #CCCCCC;
    cursor:wait;
}

function DisableButton()
{
    document.getElementById("Button1").className  = "disable";
    document.getElementById("Button1").value = '正在提交.请稍候！';
    document.getElementById("Button1").onclick=Function("return false;");
    return true;
}
document.onkeydown=mykeydown;
function   mykeydown()
{
    if(event.keyCode==116) //屏蔽F5刷新键，禁止重复提交
    {
        window.event.keyCode=0;
        return   false;
    }
}

protected void Page_Load(object sender, EventArgs e)
{       
if (!IsPostBack)
{
    this.Button1.Attributes.Add("onclick", "return DisableButton();");
}
}